“School of Cognitive Sciences”
Back to Papers HomeBack to Papers of School of Cognitive Sciences
| Paper IPM / Cognitive Sciences / 18287 |
|
||||
| Abstract: | |||||
|
Methamphetamine (METH) use disorder is a significant public health problem lacking effective and approved pharmacological treatments. Cannabidiol, a non-addictive compound derived from cannabis, has garnered attention as a potential therapeutic agent. However, the mechanisms underlying its effects on improving drug-related behaviors remain unclear. Multiple lines of evidence suggest that CBD exerts its effects by modulating the mesocorticolimbic dopamine system. D2-like receptors in the CA1 region of the hippocampus play a significant role in relaying memory and emotional signals related to the processing of drug-related cues. Therefore, this study aims to investigate the role of CA1 D2-like receptors in mediating the effects of CBD on METH-seeking behavior during extinction and reinstatement in the conditioned place preference (CPP) model. For this purpose, rats were administered various doses of Sulpiride (0.25,1, or 4 μg/0.5 μl) as a D2-like receptor antagonist before intracerebroventricular (ICV) injection of CBD (10 μg/5 μl) during a 10-day extinction period. Additionally, a separate group of rats received Sulpiride (0.25,1, or 4 μg/0.5 μl) before a single CBD injection (50 μg/5 μl) on the reinstatement day. The findings indicated that Sulpiride (1 and 4 μg) significantly attenuated CBD's acceleration of METH-CPP extinction (p < 0.01 and p < 0.05, respectively). Moreover, Sulpiride (1 and 4 μg) during the reinstatement phase notably reversed CBD's preventive effects on the reinstatement of reward-seeking behavior (p < 0.05 and p < 0.001, respectively). In summary, these results suggest that CBD's ability to shorten the extinction period and suppress METH reinstatement is partially mediated through interactions with D2-like dopamine receptors in the CA1 region of the hippocampus. These findings offering insight into more precise and effective interventions for METH use disorder.
Download TeX format |
|||||
| back to top | |||||
