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Paper   IPM / Nano-Sciences / 17755
School of Nano Science
  Title:   Gold nanosheet modified electrode with reduced impedance for electrophysiological recordings
1.  Mohaddeseh Vafaiee
2.  Farzaneh Aghakhani Mahyari
3.  Asadollah Kalantarian
4.  Mahyar Janahmadi
5.  Raheleh Mohammadpour
6.  Azam Iraji zad
7.  Pezhman Sasanpour
  Status:   Published
  Journal: Biosensors and Bioelectronics: X
  Year:  2024
  Pages:   2590-1370
  Supported by:  IPM
In neurophysiological recording, reducing electrode impedance is crucial for enhancing the signal-to-noise ratio and achieving the desired spatial resolution. This study presents an approach to improve the performance of Au/ Cr/glass electrodes by incorporating synthesized gold nanosheets without the need for additional adhesive material. We characterized the performance of the modified electrodes using electrochemical impedance spectroscopy and equivalent circuit analysis. Our findings showed an 81% reduction in mean impedance for the modified electrode, which was 0.85 kΩ at 1 kHz, compared to the unmodified electrode at 4.5 kΩ, an improvement attributed to the higher effective surface area of the modified electrode. Additionally, Scanning electron microscopy observations of PC12 cells cultured on the modified electrodes indicated favorable cell elongation and interaction with the rough surface. Stability studies indicated acceptable performance of the modified electrodes in solution environments. These results suggest that surface modification of electrodes with gold nanosheets could be a promising strategy for enhancing neural interface applications.

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