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Paper   IPM / Biological Sciences / 17744
School of Biological Sciences
  Title:   Genetic Prognostic Factors in Adult Diffuse Gliomas: A 10-Year Experience at a Single Institution
1.  Amir Barzegar Behrooz
2.  Hadi Darzi Ramandi
3.  Hamid Latifi-Navid
4.  Payam Peymani
5.  Rahil Tarharoudi
6.  Nasrin Momeni
7.  Mohammad Mehdi Sabaghpour Azarian
8.  Sherif Eltonsy
9.  Ahmad Pour-Rashidi
10.  Saeid Ghavami
  Status:   Published
  Journal: Cancers
  Year:  2024
  Supported by:  IPM
Despite recent advances in diagnosing and treating glioma, the prognosis remains poor. It is crucial to investigate its clinical characteristics and prognostic factors to provide a basis for treating and managing patients with glioma. We examined how clinical variables and molecular profiles may have affected overall survival (OS) over the past 10 years. A correlation between IDH status, TERT mutations, MGMT methylation, and tumor location characteristics was also studied. Our study demonstrates that patients with higher tumor histological grades who had received adjuvant radiotherapy exhibited isocitrate dehydrogenase 1 (IDH1) mutations or presented with wildtype telomerase reverse transcriptase promoter (TERTp) experienced improved OS.

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