“School of Biological Sciences”
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| Paper IPM / Biological Sciences / 17719 |
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Alzheimerâ??s disease (AD) is an increasingly important public health concern
due to the increasing proportion of older individuals within the general population. The impairment of processes responsible for adequate brain energy supply
primarily determines the early features of the aging process. Restricting brain
energy supply results in brain hypometabolism prior to clinical symptoms and
is anatomically and functionally associated with cognitive impairment. The
present study investigated changes in metabolic profiles induced by
intracerebroventricular-streptozotocin (ICV-STZ) in an AD-like animal model.
To this end, male Wistar rats received a single injection of STZ (3 mgkg1
) by
ICV (2.5 lL into each ventricle for 5 min on each side). In the second week
after receiving ICV-STZ, rats were tested for cognitive performance using the
Morris Water Maze test and subsequently prepared for positron emission
tomography (PET) to confirm AD-like symptoms. Tandem Mass Spectrometry
(MS/MS) analysis was used to detect amino acid changes in cerebrospinal fluid
(CFS) samples. Our metabolomics study revealed a reduction in the concentrations of various amino acids (alanine, arginine, aspartic acid, glutamic acid,
glycine, isoleucine, methionine, phenylalanine, proline, serine, threonine, tryptophane, tyrosine, and valine) in CSF of ICV-STZ-treated animals as compared to controls rats. The results of the current study indicate amino acid
levels could potentially be considered targets of nutritional and/or pharmacological interventions to interfere with AD progression.
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