“School of Nano-Sciences”
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| Paper IPM / Nano-Sciences / 17685 |
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Chronic wound healing is often a prolonged process with the migration and
proliferation of fibroblast cells playing crucial roles. Electrical stimulation (ES) has emerged
as a promising physical therapy modality to promote these key events. In this study, we
address this issue by employing a triboelectric nanogenerator (TENG) as an electrical
stimulator for both drug release and the stimulation of fibroblast cells. The flexible TENG
with a sandwich structure was fabricated using a PCL nanofibrous layer, Kapton, and silicon
rubber. The TENG could be folded to any degree and twisted, and it could return to its
original shape when the force was removed. Cultured cells received ES twice and three times
daily for 8 days, with a 30 min interval between sessions. By applying current in a safe range
and appropriate time (twice daily), fibroblasts demonstrate an accelerated proliferation and
migration rate. These observations were confirmed through cell staining. Additionally, in
vitro tests demonstrated the TENGâs ability to simultaneously provide ES and release
vitamin C from the patch. After 2 h, the amount of released drug increased 2 times in
comparison to the control group. These findings provide support for the development of a
TENG for the treatment of wounds, which underlines the promise of this new technique for developing portable electric stimulation
devices.
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