“School of Biological Sciences”

Back to Papers Home
Back to Papers of School of Biological Sciences

Paper   IPM / Biological Sciences / 17648
School of Biological Sciences
  Title:   Genome- and Exome-Wide Association Studies Revealed Candidate Genes Associated with DaTscan Imaging Features
1.  Arash Yaghoobi
2.  Homa Seyedmirzaei
3.  Moein Ala
  Status:   Published
  Journal: Parkinsonâ??s Disease
  Year:  2023
  Supported by:  IPM
Despite remarkable progress in identifying Parkinson’s disease (PD) genetic risk loci, the genetic basis of PD remains largely unknown. With the help of the endophenotype approach and using data from dopamine transporter single-photon emission computerized tomography (DaTscan), we identified potentially involved genes in PD. Method. We conducted an imaging genetic study by performing exome-wide association study (EWAS) and genome-wide association study (GWAS) on the specific binding ratio (SBR) of six DaTscan anatomical areas between 489 and 559 subjects of Parkinson’s progression markers initiative (PPMI) cohort and 83,623 and 36,845 single-nucleotide polymorphisms (SNPs)/insertion-deletion mutations (INDELs). We also investigated the association of cerebrospinal fluid (CSF) protein concentration of our significant genes with PD progression using PPMI CSF proteome data.

Download TeX format
back to top
scroll left or right