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Paper   IPM / Biological Sciences / 17642
School of Biological Sciences
  Title:   Stimulation-induced synaptic reorganization is shaped by inhibitory plasticity in a reduced model of Parkinson's disease
1.  Mojtaba Madadi Asl
2.  C.A. Lea-Carnall
  Status:   Published
  Journal: Proceedings of the 12th Basic and Clinical Neuroscience Congress
  Year:  2023
  Supported by:  IPM
The reciprocal interaction between inhibitory neurons of the globus pallidus externus (GPe) and excitatory neurons of the subthalamic nucleus (STN) forms an intrinsic pacemaker in the basal ganglia (BG). Experimental evidence suggests that exaggerated neural oscillations in the beta frequency (13-30 Hz) may be linked to the motor symptoms of Parkinson's disease (PD) and the GPe-STN network may play a central role in this process. Pathological strengthening of the inhibitory pallido-subthalamic synapses in the PD condition further exacerbates this abnormal activity which is caused by the triggering of plasticity mechanisms due to an imbalance between cortico-subthalamic and pallido-subthalamic inputs. Electrical deep brain stimulation (DBS) of the GPe or STN is a standard therapy for medically refractory PD, but its effectiveness may crucially depend on the spatio-temporal pattern of stimulation.

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