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Paper   IPM / Biological Sciences / 17573
School of Biological Sciences
  Title:   The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles
1.  Najmeh Salehi
2.  Mehdi Totonchi
  Status:   Published
  Journal: Journal of Translational Medicine
  Year:  2023
  Supported by:  IPM
To better understand the dynamics of these changes, we constructed a transcriptional cell atlas of the testis, integrating single-cell RNA sequencing data from over 26,000 cells across five developmental stages: fetal germ cells, infants, childhood, peri-puberty, and adults. We employed various analytical techniques, including clustering, cell type assignments, identification of differentially expressed genes, pseudotime analysis, weighted gene co-expression network analysis, and evaluation of paracrine cell–cell communication, to comprehensively analyze this transcriptional cell atlas of the testis.

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