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Paper   IPM / Biological Sciences / 17141
School of Biological Sciences
  Title:   Efficient suppression of parkinsonian beta oscillations in a closed-loop model of deep brain stimulation with amplitude modulation
1.  Fatemeh Bahadori-jahromi
2.  Sina Salehi
3.  Mojtaba Madadi Asl
4.  Alireza Valizadeh
  Status:   Published
  Journal: Frontiers in Human Neuroscience
  Year:  2023
  Supported by:  IPM
Parkinson's disease (PD) is a movement disorder characterized by the pathological beta band (15–30 Hz) neural oscillations within the basal ganglia (BG). It is shown that the suppression of abnormal beta oscillations is correlated with the improvement of PD motor symptoms, which is a goal of standard therapies including deep brain stimulation (DBS). To overcome the stimulation-induced side effects and inefficiencies of conventional DBS (cDBS) and to reduce the administered stimulation current, closed-loop adaptive DBS (aDBS) techniques were developed. In this method, the frequency and/or amplitude of stimulation are modulated based on various disease biomarkers.

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