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Paper   IPM / Nano-Sciences / 16911
School of Nano Science
  Title:   Non-nvasive in situ monitoring of bone scaffold activity by speckle pattern analysis
1.  Vahideh Farzam Rad
2.  Majid Panahi
3.  Ramin Jamali
4.  Ahmad Darudi
5.  Ali Reza Moradi
  Status:   Published
  Journal: Biomedical Optics Express
  No.:  11
  Vol.:  11
  Year:  2020
  Pages:   6324
  Publisher(s):   Optical Society of America under the terms of the OSA Open Access Publishing Agreement
  Supported by:  IPM
Scaffold-based bone tissue engineering aims to develop 3D scaffolds that mimic the extracellular matrix to regenerate bone defects and damages. In this paper, we provide a laser speckle analysis to characterize the highly porous scaffold. The experimental procedure includes in situ acquisition of speckle patterns of the bone scaffold at different times under preserved environmental conditions, and follow-up statistical post-processing toward examining its internal activity. The activity and overall viscoelastic properties of scaffolds are expressed via several statistical parameters, and the variations in the computed parameters are attributed to time-varying activity of the samples during their internal substructure migration.

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