“School of Biological”

Back to Papers Home
Back to Papers of School of Biological

Paper   IPM / Biological / 16199
School of Biological Sciences
  Title:   Phylogenetic and phylodynamic study of Human T-cell lymphotropic virus Type 1 (HTLV-1) in Iran
1.  Cobra Razavi Pashabayg
2.  Navid Momenifar
3.  Seyed Amir Malekpour
4.  Mehdi Sadeghi
5.  Abbas Rahimi Foroushani
6.  Houshang Rafatpanah
7.  Narges Valizadeh
8.  Faezeh Sabet
9.  Seyed Mohammad Jazayeri
10.  Hossein Keyvani
11.  Seyed Abdolrahim Rezaee
12.  Mehdi Norouzi
  Status:   To Appear
  Journal: Infection, Genetics and Evolution
  Vol.:  85
  Pages:   https://doi.org/10.1016/j.meegid.2020.104426
  Publisher(s):   Elsevier
  Supported by:  IPM
Human T-lymphotropic virus type-1 (HTLV-1) is a retrovirus that causes the neurological disorder HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP) and/or adult T-cell leukemia/lymphoma (ATLL). Iran is one of the endemic regions of the HTLV-1 in the Middle East. To infer the origin of the virus in Iran and to follow the movements of human population and routes of virus spread to this country, phylogenetic and phylodynamic analyses were performed. To this purpose, the long terminal repeat (LTR) region of HTLV-1 was used. New LTR sequences were obtained from 100 blood samples which infected with HTLV-1. Moreover, all Iranian LTR sequences which have been reported so far, were obtained from GenBank database. Sequences were aligned and maximum-likelihood and Bayesian tree topologies were explored. After identification of Iranian specific cluster, molecular-clock and …

Download TeX format
back to top
scroll left or right