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Paper   IPM / Biological / 16195
School of Biological Sciences
  Title:   Making ATP fast and slow: do yeasts play a mixed strategy to metabolise glucose?
1.  Hadiseh Safdari
2.  Mehdi Sadeghi
3.  Ata Kalirad
  Status:   Published
  Journal: bioRxiv
  Year:  2019
  Pages:   https://doi.org/10.1101/540757
  Supported by:  IPM
The ability of some microorganisms to switch from respiration to fermentation in the presence of oxygen-the so-called Crabtree effect-has been a fascinating subject of study at the theoretical and experimental fronts. Game-theoretical approaches have been routinely used to examine and explain the way a microorganism, such as yeast, would switch between the two ATP-producing pathways, i.e., respiration and fermentation. Here we attempt to explain the switch between respiration and fermentation in yeast by constructing a simple metabolic switch. We then utilise an individual-based model, in which each individual is equipped with all the relevant chemical reactions, to see how cells equipped with such metabolic switch would behave in different conditions. We further investigate our proposed metabolic switch using the game-theoretical approach. Based on this model, we postulate that individuals play a mixed game of glucose metabolism in the population. This approach not only sheds some light in the varieties of metabolic regulations that can be utilised by the individual in the population in competition with others for a common resource, it would also allow a better understanding of the causes of the Warburg effect and similar phenomena observed in nature.

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