“School of Nano-Sciences”
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| Paper IPM / Nano-Sciences / 15499 |
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The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer fluctuations. In this review, we discuss the modeling of polymer translocation in the distinct regimes of short and long polymers where these
two effects decouple. For the case of short polymers where polymer fluctuations are negligible, we present a stiff polymer model including the details of the electrohydrodynamic forces on the translocating molecule. We first show that the electrohydrodynamic theory can accurately characterize the hydrostatic pressure dependence of the polymer translocation velocity and time
in pressure-voltage-driven polymer trapping experiments. Then, we discuss the electrostatic correlation mechanisms responsible for the experimentally observed DNA mobility inversion by added multivalent cations in solid-state pores, and the rapid growth of polymer capture rates by
added monovalent salt in alpha-Hemolysin pores. In the opposite regime of long polymers where polymer
fluctuations prevail, we review the iso-flux tension propagation (IFTP) theory, which can characterize
the translocation dynamics at the level of single segments. The IFTP theory is valid for a variety
of polymer translocation and pulling scenarios. We discuss the predictions of the theory for fully
flexible and rodlike pore-driven and end-pulled translocation scenarios, where exact analytic results
can be derived for the scaling of the translocation time with chain length and driving force.
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