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Paper   IPM / Biological Sciences / 15339
School of Biological Sciences
  Title:   The Role and Importance of Genome Sequencing in Prediction of Cancer Risk
1.  Mehdi Sadeghi
2.  Hamid Pezeshk
3.  Rozbeh Tusserkani
4.  Ali Sharifi Zarchi
5.  Seyed Amir Malekpour-Nargesi
6.  Mehdi Foroughmand
7.  Sama Goliaei
8.  Mehdi Totonchi
9.  Naser Ansari-Pour
  Status:   Published
  Journal: Bioengineering and Pharmaceutical Engineering
  No.:  8
  Vol.:  11
  Year:  2017
  Pages:   455-460
  Supported by:  IPM
The role and relative importance of intrinsic and extrinsic factors in the development of complex diseases such as cancer still remains a controversial issue. Determining the amount of variation explained by these factors needs experimental data and statistical models. These models are nevertheless based on the occurrence and accumulation of random mutational events during stem cell division, thus rendering cancer development a stochastic outcome. We demonstrate that not only individual genome sequencing is uninformative in determining cancer risk, but also assigning a unique genome sequence to any given individual (healthy or affected) is not meaningful. Current whole-genome sequencing approaches are therefore unlikely to realize the promise of personalized medicine. In conclusion, since genome sequence differs from cell to cell and changes over time, it seems that determining the risk factor of complex diseases based on genome sequence is somewhat unrealistic, and therefore, the resulting data are likely to be inherently uninformative.

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