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Paper   IPM / Physic / 15069
School of Physics
  Title:   Application of new ZnO nanoformulation and Ag/Fe/ZnO nanocomposites as water-based nanofluids to consider in vitro cytotoxic effects against MCF-7 breast cance...
1.  M.H. Abdolmohammadi
2.  F. Fallahian
3.  Z. Fakhroueian
4.  M. Kamalian
5.  P. Keyhanvar
6.  F. M. Harsini
7.  A. Shafiekhani
  Status:   Published
  Journal: Artificial Cells, Nanomedicine, and Biotechnology
  Vol.:  45
  Year:  2017
  Pages:   1-9
  Supported by:  IPM
Novel formulations of nanocomposites derived from ZnO nanoparticles have provided potential biomedical applications as a new strategy for treatment of breast cancer. In this research, two types of ZnO nanomaterials were synthesized by sol–gel hydrothermal process and co-precipitation containing fast quenching and also surface modification methods. The cytotoxic effects on growth of the breast cancer cell lines MCF-7 were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Cell viability of the breast cancer cell line MCF-7 was reduced with increasing ZnO nanofluid concentrations at 48 and 72 h of treatment. The IC50 value of MCF-7 cells after 72 h of treatment with the first product ZnO (a) and second one ZnO (c) were measured as 51.02 and 48.63 μg/ml, respectively (P < 0.05).

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