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Paper   IPM / Biological / 15030
School of Biological Sciences
  Title:   Denoising of genetic switches based on Parrondos paradox
1.  Atiyeh Fotoohinasab
2.  Emad Fatemizadeh
3.  Hamid Pezeshk
4.  Mehdi Sadeghi
  Status:   Published
  Journal: Physica A: Statistical Mechanics and its Applications
  Vol.:  493
  Year:  2017
  Pages:   410-420
  Supported by:  IPM
Random decision making in genetic switches can be modeled as tossing a biased coin. In other word, each genetic switch can be considered as a game in which the reactive elements compete with each other to increase their molecular concentrations. The existence of a very small number of reactive element molecules has caused the neglect of effects of noise to be inevitable. Noise can lead to undesirable cell fate in cellular differentiation processes. In this paper, we study the robustness to noise in genetic switches by considering another switch to have a new gene regulatory network (GRN) in which both switches have been affected by the same noise and for this purpose, we will use Parrondo�??s paradox. We introduce two networks of games based on possible regulatory relations between genes. Our results show that the robustness to noise can increase by combining these noisy switches. We also describe how one of the switches in network II can model lysis/lysogeny decision making of bacteriophage lambda in E. coli and we change its fate by another switch.<br>10.1016/j.physa.2017.10.009

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