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Paper   IPM / Nano-Sciences / 14176
School of Nano Science
  Title:   ZnFe2O4 nanoparticles as radiosensitizers in radiotherapy of human prostate cancer cells
1.  Alireza Meidanchi
2.  Omid Akhavan
3.  Samideh Khoei
4.  Ali Asghar Shokri
5.  Zahra Hajikarimi
6.  Nakisa Khansari
  Status:   Published
  Journal: Material Sci. and Engineering C
  No.:  1. Jan.
  Vol.:  46
  Year:  2015
  Pages:   394-399
  Publisher(s):   Elsevier B.V.
  Supported by:  IPM
Nanoparticles of high-Z elements exhibit stronger photoelectric effects than soft tissues under gamma irradiation. Hence, they can be used as effective radiosensitizers for increasing the efficiency of current radiotherapy. In this work, superparamagnetic zinc ferrite spinel (ZnFe 2 O 4 ) nanoparticles were synthesized by a hydrothermal reaction method and used as radiosensitizers in cancer therapy. The magnetic nanoparticles showed fast separation from solutions (e.g.,  1 min for 2 mg mL �??1 of the nanoparticles in ethanol) by applying an external magnetic field ( 1 T). The ZnFe 2 O 4 nanoparticles were applied in an in vitro radiotherapy of lymph node carcinoma of prostate cells (as high radioresistant cells) under gamma irradiation of 60 Co source. The nanoparticles exhibited no significant effects on the cancer cells up to the high concentration of 100 μg mL �??1 , in the absence of gamma irradiation. The gamma irradiation alone (2 Gy dose) also showed no significant effects on the cells. However, gamma irradiation in the presence of 100 μg mL �??1 ZnFe 2 O 4 nanoparticles resulted in  53cells ( 17 times higher than the inactivation that occurred under gamma irradiation alone) after 24 h. The higher cell inactivation was assigned to interaction of gamma radiation with nanoparticles (photoelectric effect), resulting in a high level electron release in the media of the radioresistant cells. Our results indicated that ZnFe 2 O 4 nanoparticles not only can be applied in increasing the efficiency of radiotherapy, but also can be easily separated from the cell environment by using an external magnetic field after the radiotherapy.

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