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| Paper IPM / Cognitive / 13731 |
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New methods for fMRI utilize balanced steady-state free precession (b-SSFP) pulse sequences to overcome BOLD limitations [1]. The profile of b-SSFP magnetization is divided into two parts referred to as transition-band and pass-band that occur periodically [2]. BOSS fMRI creates the functional contrast in the image based on the former, where the phase is highly sensitive to the off-resonance frequency [3]. The contrast is even more enhanced at low flip angles resulting in higher SNR [3]. The crucial challenge in BOSS is its limited spatial coverage, which is resulted from the narrow transition-band in the magnetization profile [3]. Herein, we describe a new method for functional MRI, termed Averaged BOSS (A-BOSS) fMRI, in which the idea of phase transition is employed without the undesirable limited spatial coverage. The basis of this approach is described and feasibility of the proposed method is demonstrated through preliminary experimental results.
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