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Paper   IPM / Biological Sciences / 13372
School of Biological Sciences
  Title:   A Bayesian Shared Parameter Model for Analysing Longitudinal Skewed Responses with Nonignorable Dropout
1.  M. Ganjali.
2.  T. Baghfalaki.
  Status:   Published
  Journal: IJSMR
  No.:  2
  Vol.:  3
  Year:  2014
  Pages:   103-115
  Supported by:  IPM
Abstract: When the nature of a data set comes from a skew distribution, the use of usual Gaussian mixed effect model can be unreliable. In recent years, skew-normal mixed effect models have been used frequently for longitudinal data modeling in many biomedical studies. These models are flexible for considering skewness of the longitudinal data. In this paper, a shared parameter model is considered for simultaneously analysing nonignorable missingness and skew longitudinal outcomes. A Bayesian approach using Markov Chain Monte Carlo is adopted for parameter estimation. Some simulation studies are performed to investigate the performance of the proposed methods. The proposed methods are applied for analyzing an AIDS data set, where CD4 count measurements are gathered as longitudinal outcomes. In these data CD4 counts measurements are severely skew. In application section, different structures of skew-normal distribution assumptions for random effects and errors are considered where deviance information criterion is used for model comparison.

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