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Paper   IPM / Cognitive Sciences / 12824
School of Cognitive Sciences
  Title:   Influence of nitric oxide agents in the dorsal hippocampus of mice on anxiogenic-like effect induced by histamine
1.  Morteza Piri
2.  Mohammad Nasehi
3.  Malihe Asgariyan
4.  Mohammad Reza Zarrindast
  Status:   Published
  Journal: Pharmacology, Biochemistry and Behavior
  Vol.:  102
  Year:  2012
  Pages:   391-399
  Supported by:  IPM
Histaminergic receptors and neuronal nitric oxide synthase (nNOS) are co-expressed at high levels in the hippocampal neurons and alter anxiety-like behaviors in rodents. Since the dorsal hippocampus may be involved in modulation of anxiety-like behaviors, the aim of the present study was to assess whether the nitric oxide (NO) system in the dorsal hippocampus affects anxiety-like behaviors induced by histaminergic agents in mice. The effects of the NO precursor, L-arginine and NOS inhibitor, L-nitro-amino-methyl-ester (L-NAME) on histamine, pyrilamine and ranitidine responses in elevated plus maze (E.P.M.) in mice were investigated. Intra-CA1 microinjection of histamine (9 μg/mouse) or H1 receptor antagonist, pyrilamine (3, 6 and 9 μg/ mouse), but not H2 receptor antagonist, ranitidine decreased the percentage of open arm time (

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