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Paper   IPM / Cognitive Sciences / 12823
School of Cognitive Sciences
  Title:   The effects of nicotine on nitric oxide induced anxiogenic-like behaviors in the dorsal hippocampus
1.  Morteza Piri
2.  Mohammad Nasehi
3.  Zahra Shahab
4.  Mohammad Reza Zarrindast
  Status:   Published
  Journal: Neuroscience Letters
  Vol.:  528
  Year:  2012
  Pages:   93-98
  Supported by:  IPM
Nicotine, an active tobacco derived alkaloid, regulates the activity of the neuronal nitric oxide synthase (nNOS) as well as the release of nitric oxide (NO) in the nervous system. Nicotinic acetylcholine receptors and nNOS are abundantly co-expressed in the hippocampal neurons and are found to alter anxiety-like behaviors in rodents. Dorsal hippocampus may be a site for modulation of anxiety. Therefore, in this study, we investigated the possible interactions between nicotine and NO systems of the dorsal hippocampus and the resultant effect on anxiety-like behaviors. The elevated plus-maze (EPM) test has been used to test the anxiety. Intraperitoneal administration of nicotine (0.5 mg/kg) decreased the open arm time percentage (

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