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Paper   IPM / Cognitive Sciences / 12815
School of Cognitive Sciences
  Title:   Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats
1.  Behnam Yousefi
2.  Mohammad Nasehi
3.  Fatemeh Khakpai
4.  Mohammad Reza Zarrindast
  Status:   Published
  Journal: Behavioural Brain Research
  Vol.:  235
  Year:  2012
  Pages:   231-243
  Supported by:  IPM
The present study explored the possibility that cholinergic and GABAergic systems of medial septum (MS) might influence acquisition of memory by regulation of acetylcholine (Ach) and γ-aminobutyric acid (GABA) receptors function in hippocampus and vice versa. The step-through passive avoidance (PA) task was used. The results showed that pre-training intra-MS/CA1 administration of nonselective muscarinic Ach antagonist, scopolamine (0.5, 1 and 2 µg/rat) and GABAA receptor agonist, muscimol (0.01 and 0.02 µg/rat) impaired, while acetylcholinesterase inhibitor, physostigmine (0.5 and 1 µg/rat) and GABAA receptor antagonist, bicuculline (0.25 µg/rat) improved memory acquisition. Moreover, intra-CA1/MS administration of a subthreshold dose of muscimol or bicuculline increased and reversed the impairment induced by scopolamine in MS/CA1 respectively (cross injection). Also, the result revealed that, intra-CA1/MS administration subthreshold dose of muscimol reduced improvement of memory induced by physostigmine in the MS/CA1, respectively (cross injection). On the other hand, subthreshold dose of bicuculline in CA1/MS did not alter memory improvement induced by physostigmine in the other site (MS/CA1). In conclusion, both cholinergic and GABAergic systems not only seem to play a role in the modulation of memory in the MS and CA1 but also to have a complex interaction.

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