“School of Cognitive Sciences”

Back to Papers Home
Back to Papers of School of Cognitive Sciences

Paper   IPM / Cognitive Sciences / 12814
School of Cognitive Sciences
  Title:   Dopaminergic system in CA1 modulates MK-801 induced anxiolytic-like responses
1.  Mohammad Reza Zarrindast
2.  Mohammad Nasehi
3.  Mahnaz Pournaghshband
4.  Batool Ghorbani Yekta
  Status:   Published
  Journal: Pharmacology, Biochemistry and Behavior
  Vol.:  103
  Year:  2012
  Pages:   102-110
  Supported by:  IPM
Rationale: Today, there is relatively no debate on the notion that NMDA receptor antagonist agents in the hippocampus induce anxiolytic-like effects through distinct mechanisms. There is also a bulk of studies showing the involvement of the dopaminergic system in NMDA induced behaviors. Thus, on the basis of the involvement of dopaminergic system in anxiety-related behaviors, the present study aimed to investigate the involvement of the dorsal hippocampal (CA1) dopaminergic system in anxiolytic-like responses induced by MK801 (NMDA receptor antagonist) in maleWistar rats. Methods: We used the elevated plus maze to test anxiety. This apparatus has widely been employed to test parameters of anxiety-related behaviors including the open armtime percentage (

Download TeX format
back to top
scroll left or right