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Paper   IPM / Nano-Sciences / 11620
School of Nano Science
  Title:   Computational Modeling of Collective Stochastic Motion of Kinesin Nano Motors
1.  Yusef Jamali
2.  Mohammad Ebrahim Fouladvand
3.  Hashem Rafii Tabar
  Status:   Published
  Journal: Journal of Computational and Theoretical Nanoscience
  No.:  1
  Vol.:  7
  Year:  2010
  Pages:   8
  Publisher(s):   American Scientific Publishers
  Supported by:  IPM
The collective traffic of a number of kinesin protein motors, executing an asymmetric hand-over-hand motion on the microtubule track within the stochastically fluctuating intracellular medium is simulated via Brownian dynamics. The kinesin heads experience a flashing ratchet potential that models their interaction with the microtubule track, and the random hydrolysis of the ATP molecule, and a bistable potential that correlates the motion of individual heads. The overall stochastic medium within the cell is represented by white noise. Our simulation provides the average directed velocity and the of the current of kinesins along the microtubule. It is shown that beyond a certain density of kinesins, the average velocity and current undergo a notable decrease.

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