Abstract

We are involved in a large international collaboration which is studying resistance to trypanosomiasis in African cattle using a range of genomic and post-genomic strategies (large scale microarray experiments, quantitative trait loci, congenic mice, metabolic profiling etc). This work has helped us to understand in much more detail the mechanisms of resistance and susceptibility to infection ? and to surprising results around the interface between lipids and inflammation in controlling immunopathology. This has now led to interesting comparisons with serious disease in humans ? and the potential for novel treatments for patients in intensive care. The talk will also highlight some of the lessons learnt in developing an integrated computational environment for handling such diverse and complex data.



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