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| Paper IPM / Physic / 8770 |
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| Abstract: | |||||||||||
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DNA and other biomaterials that undergo translocation in small
pores con- sist of stacks of distinct bases. We consider
chaperone-assisted translocation of biopolymers with two distinct
monomers or bases, with the size of the chaperones being
λsigma, where σ is a monomer's size. A master
equation is used, together with detailed-balanced condition, as
well as Monte Carlo sim- ulation, to study the problem. Analytical
results for certain values of λ and the biopolymer's
configuration, as well as numerical values for biopolymers of size
100-900 and several λ are presented. The results indicate
sensitive dependence of the statistics of the translocation time
on the biopolymer's composition. It is also shown that
measurements of the first two moments of the biopolymer's
first-passage times provide information on its length and
ordering.
This Paper has been selected for the January 1, 2009 issue of Virtual Journal of Biological Physics Research.
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