10 MAR 2021
13:00 - 16:00

Workshop (online)
March 10 , 2021 from 13 to 16

10 MAR 2021
11:00 - 12:00

Abstract: The aim of this article is to describe a new set of nuclear parton distribution functions (nuclear PDFs) at next-to-leading order (NLO) and next-to-next-to-leading order (NNLO) accuracy in perturbative QCD. The most commonly used nuclear deep-inelastic scattering (DIS) data analyzed in this study are complemented by the available charged-current neutrino DIS experimental data with nuclear targets. The analysis also incorporates the data from Drell-Yan (DY) cross-section ratios for several nuclear targets. In addition, the most recent DIS data from the Jefferson Lab CLAS and Hall C experiments also added to our data sample. For these specific datasets, we consider the impact of the target mass corrections (TMCs) and higher twist effects (HT) which are important in the region of large x and intermediate-to-low Q2. This analysis is based on a publicly available open-source tool, APFEL, which has been modified to be applicable for our nuclear PDFs analysis. Heavy quark contributions to nuclear DIS are considered within the framework of the FONLL general mass variable-flavor-number scheme. The most recent CT18 PDFs are used as baseline proton PDFs. The uncertainties of nuclear PDFs are determined using the standard ’Hessian approach’. The main results of this global QCD analysis are compared with the existing nuclear PDF sets and with the fitted cross-sections. Very good agreement is achieved. The nuclear PDFs presented in this study are available via the standard LHAPDF library for applications in high-energy nuclear collisions.


https://arxiv.org/abs/2010.00555

Indico: https://indico.particles.ipm.ir/indico/event/406

10 MAR 2021
14:00 - 15:00

Effect of cell-like topography on drug susceptibility of breast cancer cells to doxorubicin

Abstract:

This study demonstrates the effect of substrate’s geometrical cues on viability and the efficacy of an anti-cancer drug, doxorubicin (DOX), on breast cancer cells. It is hypothesized that the surface topographical properties can mediate the cellular drug intake. Pseudo-three dimensional (3D) platforms were fabricated using imprinting technique from polydimethylsiloxane (PDMS) and gelatin methacryloyl (GelMA) hydrogel to recapitulate topography of cells’ membranes. The cells exhibited higher viability on the cell- imprinted platforms for both PDMS and GelMA materials compared to the plain/flat counterparts. The DOX response of cells was monitored for 24 h. Although imprinted substrates demonstrated enhanced biocompatibility, the cultured cells were more susceptible to the drug compared to the plain substrates. The results support that cell membrane curvature developed by multiscale topography is able to mediate intracellular signaling and drug intake.

10 MAR 2021
13:30 - 15:00

The nature of dark matter is one of the major mysteries in particle physics and cosmology. Among many dark matter scenarios, two prominent candidates are heavy WIMPs and light Axion particles. In this talk, I will start by reviewing some of the theoretical aspects of WIMPs and Axion particles as dark matter candidates. I emphasize the class of axion particles with a mass of about 10^{-22} ev and a de Broglie wavelength of the order of astrophysical distances called Fuzzy dark matter. Then I will discuss the implementation of numerical simulations for both models. In the end, I will present some of the consequences and differences between the two models derived as a result of numerical simulations in our works.