“School of Cognitive Sciences”
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| Paper IPM / Cognitive Sciences / 7446 |
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A new method for fully automated centreline extraction and quantification of microvascular structures in confocal microscopy (CM) images is presented. Our method uses the idea of active contour models as well as path planning and distance transforms for the three dimensional centreline extraction of elongated objects such as vessels. The proposed approach is especially efficient for centreline extraction of complex branching structures. The method performance is validated in several Cm images of both normal and stroked rat brains as well as simulated objects. The results confirm the efficiency of the proposed method in extracting the medical curve of vessels, which is essential for the computation of quantification parameters.
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