“School of Physic”
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| Paper IPM / Physic / 6597 |
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By exact computer enumeration and combinatorial methods, we have calculated
the designability of proteins in a simple lattice H-P model for the
protein folding problem. We show that if the strength of the non-additive part
of the interaction potential becomes larger than a critical value, the degree
of designability of structures will depend on the parameters of potential. We
also show that the existence of a unique ground state is highly sensitive to
mutation in certain sites.
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