This study presents a novel measurement system for monitoring the temperature of normal tissue during radiofrequency ablation (RFA), a critical challenge in cancer therapy. By utilizing laser beam deflection in response to temperature variations, we have proposed a sensing platform that incorporates various Au nanostructures on a glass plate as a sensing agent. The plasmon resonance behavior of these Au nanostructures is leveraged to enhance temperature sensitivity.

We compared three types of nanostructures-Au nanoparticles, Au-SiO2 core-shell structures, and Au-SiO2-Au nanomatryoshkas-to identify the optimal configuration for precise, in situ, and quasi-real-time monitoring of surrounding healthy tissue during RFA. The results demonstrate that the Au-SiO2-Au nanomatryoshka is the best Au nanostructure for this sensing platform, as it causes the greatest changes in laser beam deflection and exhibits significant variations in absorption based on temperature and wavelength.

Our findings highlight the potential of this system to significantly improve patient safety by enabling effective temperature management during treatment.