“School of Nano-Sciences”
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| Paper IPM / Nano-Sciences / 16516 |
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The optical polarization properties of virus-infected cells have been measured, analyzed, and compared
with the uninfected cells. In this regard, Vero and HeLa cells have been used as the host for Herpes
simplex viruses (HSV). By using polarization microscopy imaging technique, the Mueller matrix images
of infected and uninfected cells have been recorded. Through image processing and further analysis, the
polarization properties of host cells are compared with their infected ones. For quantitative analysis, the
multispectral Mueller matrix transformation (MMT) parameters (A and b) are calculated to identify the
microstructural differentiations between uninfected and infected cells by HSV. The results of our study
show that the structural dependent polarization parameters of A and b are sensitive to the infection situation while, the effect of infection on different cells could be distinguished through these parameters accordingly. The polarimetric microscopy imaging and extracted polarization parameters could be considered as an impressive competitor for time-consuming, expensive, and operator dependent available techniques.
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