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| Paper IPM / Cognitive Sciences / 13962 |
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The present study investigated the possible alterations of hippocampal CREB phosphorylation in drugstate-dependent memory retrieval. One-trial step-down passive avoidance task was used to assessmemory retrieval in adult male NMRI mice. Pre-training administration of ethanol (1 g/kg, i.p.) inducedamnesia. Pre-test administration of ethanol (1 g/kg, i.p) or nicotine (0.7 mg/kg, s.c.) reversed ethanol-induced amnesia, indicating ethanol- or ethanol�??nicotine induced state-dependent learning (STD). UsingWestern blot analysis, it was found that the p-CREB/CREB ratio in the hippocampus increased in the micethat showed successful memory retrieval as compared with untrained mice. In contrast, pre-trainingadministration of ethanol (1 g/kg, i.p.) decreased the hippocampal p-CREB/CREB ratio in comparisonwith the control group. The hippocampal p-CREB/CREB ratio enhanced in ethanol- and ethanol�??nicotineinduced STD. Moreover, memory impairment induced by pre-training administration of WIN (1 mg/kg,i.p.) improved in the animals that received pre-test administration of WIN (1 mg/kg, i.p.), ethanol (0.5 g/kg,i.p.) or nicotine (0.7 mg/kg, s.c.), suggesting a cross STD between the drugs. The p-CREB/CREB ratio in thehippocampus decreased in the of WIN-induced amnesia and STD groups in comparison with the controlgroup. In addition, cross state-dependent learning between WIN and ethanol or nicotine was associatedwith the increase of the hippocampal p-CREB/CREB ratio. It can be concluded that phosphorylation ofCREB in the hippocampus is a critical event underlying the interaction of co-administration of drugs onmemory retrieval in passive avoidance learning.
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