“School of Cognitive Sciences”
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| Paper IPM / Cognitive Sciences / 12168 |
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Cholestasis is associated with endotoxinemia and elevated serum levels of bile acids, cholesterol, bile salts and opioids. Opioid systems have been reported to modulate anxiety. In the present study, the possible involvement of opioidergic system on anxiolytic-like behaviors induced by cholestasis was investigated. Cholestasis was induced in male Wistar rats by ligation of the main bile duct using two ligatures and transecting the duct at the midpoint between them. A standard elevated plus-maze was used to determine anxiety levels in animals. The data indicated that there is an increase, 13 days (but not 10 days) after bile duct ligation, in the percentage of open arm time (
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