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Sunday 26 March 2023   Today  
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Memory Deficit in Temporal Lobe Epilepsy



Memory impairment is a common cognitive deficit in temporal lobe epilepsy (TLE). The hippocampus is severely altered in TLE exhibiting multiple anatomical changes that lead to a hyperexcitable network capable of generating frequent epileptic discharges and seizures. In this study we investigated whether hippocampal involvement in epileptic activity drives working memory deficits. We employed the supra-hippocampal kainic acid (KA) mouse model of TLE. We observed a working memory deficit in epileptic mice in a delayed-alternation spatial working memory task. We further ...