| Saturday 6 July 2024 | |
| Events for day: Thursday 09 November 2023 |
| 10:00 - 12:30 Weekly Seminar A deep learning model for predicting the presence of ncRNAs in exosomes School BIOLOGICAL SCIENCES Small non-coding RNAs can be secreted through a variety of mechanisms, including exosomal sorting, in small extracellular vesicles, and within lipoprotein complexes. However, the mechanisms that govern their sorting and secretion are still not well understood. In this talk, which is done in collaboration with Dr. Hani Goudarzi lab at UCSF, we will present ExoGRU, a machine-learning model that predicts small RNA secretion probabilities from primary RNA sequence. We experimentally validated the performance of this model through ExoGRU-guided mutagenesis and synthetic RNA sequence analysis and confirmed that primary RNA sequence is a major deter ... |