| Saturday 6 July 2024 | |
| Events for day: Thursday 28 September 2023 |
| 10:00 - 12:30 Weekly Seminar Single-cell multi-omics analysis identifies context specific gene regulatory gates and mechanisms School BIOLOGICAL SCIENCES Deciphering tissue- and cell-type specific gene regulatory networks from single-cell RNA sequencing (scRNA-seq) represents an area of active research. While past efforts have focused on reconstructing directed transcription factor (TF) to target gene networks, logic-based models enable interrogation of more complex combinatorial relationships between regulators. In particular, Boolean logic models can capture higher-order TF interactions, represented through AND, OR, and XOR logic gates. We propose a novel approach for inferring TF-gene networks from scRNA-seq while simultaneously elucidating the underlying Boolean logic combining TF activiti ... |