“School of Biological Sciences”
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| Paper IPM / Biological Sciences / 17744 |
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| Abstract: | |||||||||||||||||||||
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Despite recent advances in diagnosing and treating glioma, the prognosis remains
poor. It is crucial to investigate its clinical characteristics and prognostic factors to provide a basis
for treating and managing patients with glioma. We examined how clinical variables and molecular
profiles may have affected overall survival (OS) over the past 10 years. A correlation between IDH
status, TERT mutations, MGMT methylation, and tumor location characteristics was also studied. Our
study demonstrates that patients with higher tumor histological grades who had received adjuvant
radiotherapy exhibited isocitrate dehydrogenase 1 (IDH1) mutations or presented with wildtype
telomerase reverse transcriptase promoter (TERTp) experienced improved OS.
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