| Friday 19 April 2024 | |
| Events for day: Thursday 14 March 2019 |
| 10:00 - 11:00 Weekly Seminar Drug combination prediction to target heterogeneous clones of tumor School BIOLOGICAL SCIENCES Problem: Brain tumours remain a largely incurable disease, with glioblastoma multiforme (GBM) representing the predominant form of malignancy. GBMs tend to display highly variable features, which likely underlies the resistance to monotherapies. Hence, a shift away from the single-drug paradigm for new therapeutic strategies is becoming increasingly necessary. We address this issue by finding efficient drug combinations targeting multiple clones of tumour simultaneously by analysing single-cell RNA-seq data of the GBM samples. Models: We develop new predictive models of drug response trained with large amount of preclinical pharmacogenomic da ... |