IPM Calendar 
Saturday 18 November 2017   Today  
Events for day: Thursday 23 November 2017    
           10:00 - 11:00     Seminar
MuClone: Somatic mutation detection and classification through probabilistic integration of clonal population structure

School
BIOLOGICAL SCIENCES

Abstract:
Accurate detection and classification of somatic single nucleotide variants (SNVs) is important in defining the clonal composition of human cancers. Existing tools are prone to miss low prevalence mutations and methods for classification of mutations into clonal groups across the whole genome are underdeveloped. Increasing interest in deciphering clonal population dynamics over multiple samples in time or anatomic space from the same patient is resulting in DNA sequencing data from phylogenetically related samples. With the access to this data, we posited that injecting clonal structure information into the inference of muta ...